EMBAR

Author:
Kunwar Abdul Kalam , Dr. Suneel Kumar Niranjan
Research Scholar ,Institute of Pharmacy, Bundelkhand University, Jhansi

Published Date: 21-Jul, 2023

Keywords: Preformulation study; Propranolol hydrochloride; Formulation development; Calibration curve; Excipient compatibility

Abstract:
This preformulation study aimed to characterize the chemical and physical properties of propranolol hydrochloride, a commonly used beta-blocker drug, in order to provide essential information for the formulation design and development process. A key aspect of the study involved the preparation of a standard calibration curve using a methanol solution, which exhibited a high coefficient of determination (r2) value exceeding 0.996, indicating a strong correlation between measured concentrations and absorbance values. The calibration curve demonstrated excellent adherence to the Beer-Lambert law within the conc. range of 4-20 mcg/ml, suggesting the reliability and suitability of the developed analytical approach for accurately quantifying propranolol hydrochloride in this range. The utilization of phosphate buffer of pH 6.8 as the medium for spectrophotometric measurements further supported the method's accuracy within the conc. range of 10-50 µg/ml. However, it is important to conduct compatibility studies between the drug substance and excipients to evaluate potential interactions that could impact product stability or performance. Overall, this preformulation study provides a solid foundation for the formulation development of propranolol hydrochloride, offering a well-established calibration curve, a robust quantification method, and highlighting the importance of excipient compatibility assessment.

References: