EMBAR

Author:
Pratik Kumar Vishwakarma *, Vivek Gupta, Yogesh Kumar, Gyan Singh
Pratik Kumar Vishwakarma

DOI: doi.org/10.58924/rjams.v4.iss2.p2

Published Date: 01-Jan, 1970

Keywords: Boswellia serrata, Glucose regulation, Pancreatic protection, Bioactive compounds, Antidiabetic potential .

Abstract:
Background – Diabetes and its complications pose a global health crisis, emphasizing the need for therapeutic approaches that not only regulate glucose but also protect pancreatic function. Boswellia serrata Roxb, a traditional medicinal plant, has gained attention for its bioactive compounds that offer dual benefits for glucose regulation and pancreatic protection. This review explores its phytochemical profile, mechanisms of action, and translational potential in diabetes management. Methods An in-depth review of studies was conducted to analyze the phytochemistry, pharmacological effects, and therapeutic applications of Boswellia serrata. Key bioactive were identified using advanced techniques such as HPLC and GC-MS. Mechanistic insights into glucose modulation, beta-cell protection, and anti-inflammatory pathways were evaluated. The impact of novel drug delivery systems, including nano formulations, on enhancing efficacy was also investigated. Results Boswellia serrata is rich in bioactive such as boswellic acids, terpenoids, and flavonoids, which improve glucose homeostasis by enhancing insulin sensitivity, activating AMPK pathways, and inhibiting alpha-glucosidase. Its antioxidant and anti-inflammatory properties protect pancreatic beta cells from oxidative stress and inflammatory damage. Preclinical studies demonstrate significant antidiabetic potential, while early clinical trials suggest safety and efficacy. Innovations in formulations, including nanoparticles, further enhance bioavailability and therapeutic outcomes. Conclusion With its multifaceted pharmacological profile, Boswellia serrata offers a promising avenue for addressing diabetes and pancreatic dysfunction. Future research should prioritize clinical validation, standardization, and innovative delivery systems to harness its full therapeutic potential..

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